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Last name origins & meanings:

1. English: metonymic occupational name for a maker and seller of gloves or a nickname for a wearer of particularly fine gloves, from Middle English cuffe ‘glove’ (of uncertain origin; attested in this sense from the 14th century, with the modern meaning first in the 16th century).
2. Irish: Anglicized form of Gaelic Mac Dhuibh, a variant of Mac Duibh ‘son of the black one’ (see Duff).
3. Irish: approximate translation of Gaelic Ó Doirnín (see Dornan).
4. Cornish: nickname from Cornish cuf ‘dear’, ‘kind’.